Understanding Testosterone Replacement Therapy: A Complete Guide for Men Over 50
Learn about the benefits, risks, and what to expect from TRT treatment for men experiencing low testosterone.
Dr. Sarah Johnson
Hormone Specialist

As men age, testosterone levels naturally decline, typically beginning around age 30 and continuing at a rate of about 1% per year. For many men over 50, this decline can lead to significant symptoms that impact quality of life, energy levels, and overall well-being.
What is Testosterone Replacement Therapy?
Testosterone Replacement Therapy (TRT) is a medical treatment designed to restore testosterone levels to a healthy range in men diagnosed with clinically low testosterone, also known as hypogonadism or "Low T."
Common Symptoms of Low Testosterone
Men experiencing low testosterone may notice several symptoms:
- Decreased energy and fatigue
- Reduced muscle mass and strength
- Increased body fat, particularly around the midsection
- Decreased libido and sexual function
- Mood changes, including depression or irritability
- Difficulty concentrating or "brain fog"
- Sleep disturbances
- Decreased bone density
Benefits of TRT
When properly administered and monitored, TRT can provide significant benefits:
- Increased Energy: Many men report feeling more energetic and motivated
- Improved Body Composition: Increased muscle mass and reduced body fat
- Enhanced Mood: Better emotional well-being and reduced depression
- Better Sleep: Improved sleep quality and duration
- Cognitive Function: Enhanced focus and mental clarity
- Sexual Health: Improved libido and sexual function
Types of TRT
There are several methods of testosterone delivery, each with its own advantages:
- Injections: Administered weekly or bi-weekly, providing consistent levels
- Topical Gels: Applied daily to the skin for steady absorption
- Patches: Worn on the skin and changed daily
- Pellets: Implanted under the skin every 3-6 months
Who is a Candidate for TRT?
TRT is appropriate for men who have been diagnosed with clinically low testosterone through blood testing and are experiencing symptoms that impact their quality of life. Candidates should:
- Have confirmed low testosterone levels through multiple blood tests
- Be experiencing symptoms consistent with low testosterone
- Have no contraindications such as prostate cancer or severe heart disease
- Be committed to regular monitoring and follow-up care
Potential Risks and Side Effects
Like any medical treatment, TRT carries potential risks that should be discussed with your healthcare provider:
- Increased red blood cell count
- Sleep apnea
- Acne or oily skin
- Breast enlargement
- Testicular shrinkage
- Decreased sperm production
The Importance of Medical Supervision
TRT should always be conducted under the supervision of a qualified healthcare provider. Regular monitoring includes:
- Periodic blood tests to monitor testosterone levels
- Prostate health screenings
- Cardiovascular health assessments
- Bone density evaluations
- Regular symptom assessments
Getting Started with TRT
If you're considering TRT, the first step is to consult with a healthcare provider who specializes in hormone therapy. They will:
- Conduct a comprehensive health evaluation
- Order appropriate blood tests
- Discuss your symptoms and health goals
- Develop a personalized treatment plan
- Provide ongoing monitoring and support
Remember, TRT is not a one-size-fits-all solution. What works for one person may not work for another, which is why personalized care and regular monitoring are essential for safe and effective treatment.
Ready to Explore Your Options?
Schedule a free consultation with one of our hormone specialists to discuss if TRT is right for you.